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Nadine Schaadt

Address

Email: nschaadt[insert at]bioinformatik.uni-saarland.de                  
 
Telephone: ++49 +681 302 70710

Fax: ++49 +681 302 70702

Postal address:

Center for Bioinformatics

Gebaeude E2 1, R. 303
P.O. Box 15 11 50
D-66041 Saarbruecken
Germany


 

 

 

Curriculum Vitae

PhD student, Center for Bioinformatics, Saarland University (10.2009-08.2013) 

M.Sc. in Bioinformatics at Saarland University, Saarbrücken, Germany (2009)

          Master's Thesis: Substrate Prediction of Membrane Transporters in Arabidopsis thaliana

B.Sc. in Computational Molecular Biology at Saarland University, Saarbrücken, Germany (2008)

          Bachelor's Thesis: Quantitative Analysis of Quorum Sensing in Vibrio fischeri

 

Research Areas

functional classification and annotation of membrane proteins

          - statistical analysis of protein sequences and sequence-based features

            (amino acid composition, topology information, multiple sequence alignments, physicochemical characteristics)

          - prediction of protein families and transported substrates using machine learning tools (a ranking method for small data sets)

modeling Quorum sensing and virulence factor formation in Pseudomonas aeruginosa

           - analysis of the signaling pathway by simulating combined regulatory and metabolic networks

           - to search for enzyme inhibitors or receptor antagonists that combat bacterial resistance

           - extended multi-level logical formalism

 

List of Publications

Schaadt, N.S., Steinbach, A., Hartmann, R.W., and Helms, V. Rule-based regulatory and metabolic model Quorum sensing in P. aeruginosa. Vol. 7, 81. BMC Systems Biology (2013)

Schaadt, N.S. and Helms, V., "Functional classication of membrane transporters and channels based on filtered TM/non-TM amino acid composition", Vol. 97, p. 558-567. Biopolymers (2012)

Metzger, J., Schaadt, N.S., Hayat, S., and Helms, V., "Predicting structural and functional properties of membrane proteins from protein sequence", Vol. 7, p. 39-64. Ed. Wheeler, R.A. Annual Reports in Computational Chemistry (2011)

Schaadt, N.S., Christoph, J., and Helms, V., Classifying substrate specifities of membrane transporters from arabidopsis thaliana., Vol. 50, p. 1899-1905, Journal of Chemical Information and Modeling (2010)

 

List of Posters

"Computational Systems Biology Methods", Computational Biology @ Bayer workshop, Leverkusen, Germany (2013)

"Extended multi-level logical regulatory and metabolic Model for Quorum Sensing in Pseudomonas aeruginosa", ISMB/ECCB, Berlin, Germany (2013)

"Classification of Membrane Proteins", GRC Mechanisms of Membrane Transport, University of New England, USA (2011)

"Classifying Substrate Specificities of Membrane Transporters from Arabidopsis thaliana", ECCB, Ghent, Beligum (2010)

Teaching

WS12/13:

Bioinformatics III

Softwarewerkzeuge der Bioinformatik

Pro-/Seminar: Modeling of Bacterial Resistance

 

WS11/12:

Bioinformatics III

Softwarewerkzeuge der Bioinformatik


SS11:

Softwarewerkzeuge der Bioinformatik

 

WS10/11:

Bioinformatics III

Pro-/Seminar: Statistical Methods in Bioinformatics

 

SS10:

Softwarewerkzeuge der Bioinformatik


WS09/10:

Bioinformatics III

Pro-/Seminar: Selected Topics from Membrane Bioinformatics 

 

SS09:

Softwarewerkzeuge der Bioinformatik

 


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