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PROPORES page

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 The logo is designed by Ting-Yen Chang.

 

Introduction

 “PROPORES” is a novel toolkit for identifying pockets, cavities and channels of protein structures. The toolkit was developed in PERL programming language and includes “PoreID” for pore identification, “PoreTrace” for pore axes determination and “GateOpen” for opening the gate between neighboring pores. “PoreID” is a grid-based method that avoids orientation dependency of the results. It targets all kinds of pores (pockets, cavities and channels) and is automatic so that only the PDB file of the target protein has to be specified by the user. Several descriptors of pores such as volume, lining residues, axes, and radius profiles are provided by “PoreID” and “PoreTrace”. In addition, for two neighboring pores, “GateOpen” can be used to test connectivity by rotating side chains of the gating residues. This was done to introduce a dynamic variable into the pore identification of the otherwise static protein structure.

 

Scheme of the toolkit

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Download

Here you can download the PROPORES software.

 

Reference

Lee PH, Helms V. Identifying continuous pores in protein structures with PROPORES by computational repositioning of gating residues. Proteins 2012;80(2):421-432.

 

Contact

Po-Hsien Lee

p.lee@mx.uni-saarland.de

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