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Spezialvorlesung: Modern Methods in Drug Discovery WS 08/09

General Information

Lecturer: Dr. Michael Hutter

Tutor: Dr. Michael Hutter

Lecture: Monday, 10:15 am - 11:45 am, building E 1 3, R 0.16
Tutorial: Wednesday, 10:15 am - 11:45 am, CIP Pool Bioinformatik, room 103, every second week

Information: This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Note: This course will be presented in English, the final exam will be available in German too.


  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik

This questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.

Registration: via E-mail starting October by name and Matrikelnr.
to:  Kerstin Gronow-Pudelek

Students that have successfully passed the following courses
will be considered in the first place:
Bioinformatik I
Bioinformatik II
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik

Master course students with a bachelor degree from another university can also take part if successful participation of equivalent courses has been proved.


Scope: The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design

Schein/Certification: Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam: At least 50% of the points of the assignments.

Date of the exam: February 2, 2009, 10:15 am - 11:45 am; building E1 3, R. 0.16

RESULTS of the exam of February 2

Leistungspunkte/Credits: 5 (2 V + 1 Ü)

This course is taught in English. 


1st Lecture, October 27 pdf pps

2nd Lecture, November 3  pdf pps 1st Tutorial    
3rd Lecture, November 10 pdf pps

4th Lecture, November 17 pdf pps 2nd Tutorial  
5th Lecture, November 24 pdf pps   
6th Lecture, December 1 pdf pps 3rd Tutorial  
7th Lecture, December 8 pdf pps  

8th Lecture, December 15 pdf pps 4th Tutorial
9th Lecture, January 5 pdf pps  
10th Lecture, January 12 pdf pps Jan. 12: no lecture,
Jan. 14: no tutorial
11th Lecture, January 19 pdf

12th Lecture, January 26 pdf
6th Tutorial  
February 2      EXAM
13th Lecture, February 9


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