Spezialvorlesung: Modern Methods in Drug Discovery WS 09/10

Lecturer: Dr. Michael Hutter

Tutor: Dr. Michael Hutter

Lecture: Monday, 10:15 am - 11:45 am, building E 1 3, R 0.15
Tutorial: Wednesday, 10:15 am - 11:45 am, CIP Pool Bioinformatik, room 104, every second week

Information: This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Note: This course will be presented in English, the final exam will be available in German too.

Requirements:

• basic knowledge of Organic Chemistry and Genetics
• scope of the lectures:
  Bioinformatik I + II
  Computational Chemistry
  Softwarewerkzeuge der Bioinformatik
  

The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.

Registration: via E-mail starting October by name and Matrikelnr.
to:  Kerstin Gronow-Pudelek

Students that have successfully passed the following courses
will be considered in the first place:
Bioinformatik I
Bioinformatik II
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik

Master course students with a bachelor degree from another university can also take part if successful participation of equivalent courses has been proved.

Scope: The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

• molecular origin of typical diseases and the mode of action of drugs
• virtual substance libraries and query strategies
• in silico eADMET models and filters, bioavailability
• statistics and QSAR methods
• metabolism, toxicology and adverse side effects, also considering biomarkers
• polymorphism and susceptible genes
• identification of orthologous genes to derive new targets and model organisms
• current trends and strategies of drug design

Schein/Certification: Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam: At least 50% of the points of the assignments.

Date of the exam: January 25th, 2010, 10:15 am. Builidng E2.1 (next to Library) Room 0.07 (ground floor).

RESULTS of the examination of Monday, January 25

Leistungspunkte/Credits: 5 (2 V + 1 Ü)

This course is taught in English.

Lectures: