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Special-topic Lecture: Modern Methods in Drug Discovery WS 11/12

General Information

Lecturer: Dr. Michael Hutter

Tutor: Dr. Michael Hutter

Lecture: Monday, 10:15 am - 11:45 am, building E2 1, room 007
Tutorial: Tuesday, 12:30 am - 02:00 pm, starting on November 8, every second week, E2 1, CIP Pool 003

Information: This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Note: This course will be presented in English, the final exam will be available in German too.

Requirements:

  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik

The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.


Students that have successfully passed the following courses
will be considered in the first place:
Bioinformatik I
Bioinformatik II
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik


Master course students with a bachelor degree from another university can also take part if successful participation of equivalent courses has been proved.

 

Scope: The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design


Schein/Certification: Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam: At least 50% of the points of the assignments.

Leistungspunkte/Credits: 5 (2 V + 1 Ü)

This course is taught in English.

Lectures:

Lecture 1, October 24 pdf
ppt
Assignment 1
no Lecture on October 31



Lecture 2, November 7 pdf
ppt

Tutorial 1, November 8 (CIP-room)



Lecture 3, November 14
pdf
ppt
Assignment 2
Lecture 4, November 15 (CIP-room)
pdf
ppt

Lecture 5, November 21
pdf
ppt
Assignment 3
Tutorial 2, November 22 (CIP-room)



Lecture 6, November 28
pdf
ppt

Lecture 7, December 5
pdf
ppt
Assignment 4
Tutorial 3, December 6 (CIP-room)



Lecture 8, December 12
pdf
ppt

Lecture 9, December 19
pdf
ppt
Assignment 5
Tutorial 4, December 20 (CIP-room)



Lecture 10, January 9
pdf
ppt

Lecture 11, January 16
pdf
ppt

Exam, January 23



January 30


Exam evaluation
Lecture 12, February 6
pdf
ppt

 

 

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