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Special-topic Lecture: Modern Methods in Drug Discovery WS 14/15

General Information

Lecturer: Dr. Michael Hutter

Tutor: Dr. Michael Hutter

Lecture: Monday, 10:15 am - 11:45 am, building E2 1, room 007, starting on October 27

Tutorial: Building E2 1, CIP Pool 003, every second week, Thursdays, 04:15 pm - 05:45 pm, Dates: see below

Information: This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Exam: Monday, February 2, 2015, 10:15 am - 11:45 am, E2 1, room 007

Re-exam: Tuesday, April 21, 2015, 4:00 pm, in E2 1, room 007

Note:

This course will be presented in English, the final exam will be available in German too.

Re-exam: Tuesday, April 21, 4:00 pm - 5:30 pm, E2 1, room 007

Requirements:

  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik

The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.


Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik

 

Scope: The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design


Schein/Certification: Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam: At least 50% of the points of the assignments.

Leistungspunkte/Credits: 5 (2 V + 1 Ü)

This course is taught in English.

Lectures:

Lecture 1, October 27 pdf
Assignment 1
Lecture 2, November 3
pdf

Tutorial 1,  November 6 (CIP-room)
Exercise 1

Lecture 3, November 10 pdf
Assignment 2
Lecture 4, November 17
pdf

Tutorial 2, November 20 (CIP-room)
Exercise 2

Lecture 5, November 24
pdf
Assignment 3
Lecture 6, December 1
pdf

Tutorial 3, December 4 (CIP-room)
Exercise 3

Lecture 7, December 8
pdf
Assignment 4
Lecture 8, December 15
pdf

Lecture 9, January 5
pdf
Assignment 5
Lecture 10, January 12
pdf

Tutorial 4, January 15 (CIP-room)
Exercise 4
Lecture 11, January 19
pdf

Lecture 12, January 26
pdf

February 2, Exam


February 9
exam
evaluation

 

 

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