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Special-topic Lecture: Modern Methods in Drug Discovery WS 15/16

General Information

Lecturer: Dr. Michael Hutter

Tutor: Dr. Michael Hutter

Lecture: Monday, 10:15 am - 11:45 am, building E2.1, room 007, starting on October 26

Tutorial: Building E2 1, CIP Pool 003, every second week, Thursdays, 04:15 pm - 05:45 pm, Dates: see below

Information: This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Exam:  Monday, February 1st, 10:15 am, in E2.1, room 007

These are the results of the exam.

The re-exam will take place on Wednesday, April 20th, at 04:00 pm in E2.1, room 007.


This course will be presented in English, the final exam will be available in German too.


  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik

The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.

Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master program Bioinformatics)
Computational Chemistry
Softwarewerkzeuge der Bioinformatik


Scope: The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design

Schein/Certification: Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam: At least 50% of the points of the assignments.

Leistungspunkte/Credits: 5 (2 V + 1 Ü)

This course is taught in English.


Lecture 1, October 26 pdf
Assignment 1
Lecture 2, November 2

Lecture 3, November 9 pdf
Assignment 2
Tutorial 1,  November 12 (CIP-room)
Exercise 1
Exercise 1
Lecture 4, November 16

Lecture 5, November 23
Assignment 3 MX data set
Tutorial 2, November 26 (CIP-room)
Exercise 2
Exercise 2
Lecture 6, November 30

Lecture 7, December 7
Assignment 4
Tutorial 3, December 10 (CIP-room)
Exercise 3
Exercise 3
Lecture 8, December 14

Lecture 9, January 4
Assignment 5
Tutorial 4, January 7 (CIP-room)
Exercise 4
Exercise 4
Lecture 10, January 11

Lecture 11, January 18

Tutorial 5, January 21 (CIP-room)
Lecture 12, January 25

Exam, February 1



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