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Special-topic Lecture: Modern Methods in Drug Discovery WS 12/13

General Information

Lecturer: Dr. Michael Hutter

Tutor: Dr. Michael Hutter

Lecture: Monday, 10:15 am - 11:45 am, building E2 1, room 007, starting on October 22

Tutorial: Building E2 1, CIP Pool 003, roughly every second week Fridays 15:00 to 16:30. Starting November, 9th.

Information: This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Exam: Will take place on Monday, January 28th, 2013, in E2 1, 003 and 007.

Note: This course will be presented in English, the final exam will be available in German too.

Requirements:

  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik

The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.


Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik

 

Scope: The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design


Schein/Certification: Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam: At least 50% of the points of the assignments.

Date of the exam: January 28th, 2013.  RESULTS

EXAM REVIEW: Tuesday, February 19, 2:00 pm, E2 1, room 3.13

Date of the written re-exam: Monday, April 15, 2:00 pm, E2 1, room 007    RESULTS

Leistungspunkte/Credits: 5 (2 V + 1 Ü)

This course is taught in English.

Lectures:

Lecture 1, October 22 pdf
Assignment 1
Lecture 2, October 29
pdf

Lecture 3, November 5 pdf
Assignment 2
Tutorial 1, November 9 (CIP-room)
Exercise 1

Lecture 4, November 12
pdf

Lecture 5, November 19
pdf
Assignment 3
Tutorial 2, November 23 (CIP-room)
Exercise 2

Lecture 6, November 26
pdf

Lecture 7, December 3
pdf
Assignment 4
Tutorial 3, December 7 (CIP-room)


Lecture 8, December 10
pdf

Tutorial 4, December 14 (CIP-room)
Exercise 4

Lecture 9, December 17
pdf

Lecture 10, January 7
pdf
Assignment 5
Lecture 11, January 14
pdf

Lecture 12, January 21
pdf

Exam, January 28


Lecture 14, February 4 Exam evaluation



 

 

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