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Special-topic Lecture: Modern Methods in Drug Discovery WS 13/14

General Information

Lecturer: Dr. Michael Hutter

Tutor: Dr. Michael Hutter

Lecture: Monday, 10:15 am - 11:45 am, building E2 1, room 007, starting on October 21

Tutorial: Building E2 1, CIP Pool 003, every second week, Thursdays, 04:15 pm - 05:45 pm, Dates: 31.10., 14.11., 28.11., 12.12.2013, 09.01.2014, 22.01.2014

Information: This course can be used as a "Spezialvorlesung der Bioinformatik/Special-topic Lecture Bioinformatics"

Exam: Friday, January 31, 1:15 pm - 3:00 pm in E2 1, room 007

Date of re-exam: Wednesday, April 9, 2:00 pm, E2 1, room 007

Note: This course will be presented in English, the final exam will be available in German too.

Requirements:

  • basic knowledge of Organic Chemistry and Genetics
  • scope of the lectures:
    Bioinformatik I + II
    Computational Chemistry
    Softwarewerkzeuge der Bioinformatik

The questionnaire gives you an idea about the required knowledge.
Due to the limited capacity of the room, the number of participants
will be limited to about 20.


Students need to have successfully passed one of the following courses to be admitted:
Bioinformatik II
Bioinformatics III (Master program Bioinformatics)
Computational Chemistry I
Softwarewerkzeuge der Bioinformatik

 

Scope: The focus of this course is the computer based prediction of suitable pharmaceutical drugs and the search for new potential targets in the human genome. Following topics are covered:

  • molecular origin of typical diseases and the mode of action of drugs
  • virtual substance libraries and query strategies
  • in silico eADMET models and filters, bioavailability
  • statistics and QSAR methods
  • metabolism, toxicology and adverse side effects, also considering biomarkers
  • polymorphism and susceptible genes
  • identification of orthologous genes to derive new targets and model organisms
  • current trends and strategies of drug design


Schein/Certification: Grade of certification ("Schein") is based on the final exam only.

Condition for participation in the final exam: At least 50% of the points of the assignments.

Leistungspunkte/Credits: 5 (2 V + 1 Ü)

This course is taught in English.

Lectures:

Lecture 1, October 21 pdf
Assignment 1
Lecture 2, October 28
pdf

Tutorial 1, October 31(CIP-room)
Exercise 1

Lecture 3, November 4 pdf
Assignment 2
Lecture 4, November 11
pdf

Tutorial 2, November 14 (CIP-room)

Exercise 2

Lecture 5, November 18
pdf
Assignment 3
Lecture 6, November 25
pdf

Tutorial 3, November 28(CIP-room)

Exercise 3

Lecture 7, December 2
pdf

Assignment 4
December 9
No lecture!

Tutorial 4, December 12 (CIP-room)
printed handout

Lecture 8 & 9, December 16
pdf pdf

Assignment 5

Lecture 10, January 6
pdf

Tutorial 5, January 9 (CIP-room)

Exercise 5

Lecture 11, January 13
pdf

Lecture 12, January 20
pdf

January 27
no lecture

January 31
exam
February 3
Exam evaluation

 

 

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